Abstract
Background Hypersensitivity reactions to parenteral administered antibiotics (HRPA) are a substantial problem in managing pulmonary disease in Cystic Fibrosis (CF), especially in advanced CF. This group of patients requires a life long antibiotic treatment with extremely high cumulative doses compared to other patients. In our daily routine we observed a growing number of hypersensitivities. Therefore we conducted this observational study to assess HRPA s impact on the daily clinical work with CF, as well as it’s nature, frequency and predisposing risk factors.
Highlights
Hypersensitivity reactions to parenteral administered antibiotics (HRPA) are a substantial problem in managing pulmonary disease in Cystic Fibrosis (CF), especially in advanced CF
Our results demonstrate that HRPA with a prevalence of 60% are very relevant
During days 1-4 of antibiotic treatment courses patients might be at elevated risk to experience HRPA
Summary
Hypersensitivity reactions to parenteral administered antibiotics (HRPA) are a substantial problem in managing pulmonary disease in Cystic Fibrosis (CF), especially in advanced CF. This group of patients requires a life long antibiotic treatment with extremely high cumulative doses compared to other patients. In our daily routine we observed a growing number of hypersensitivities. We conducted this observational study to assess HRPAs impact on the daily clinical work with CF, as well as it’s nature, frequency and predisposing risk factors
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