Hypersensitivity to Nadroparin Calcium

Abstract

The use of heparin to prevent or treat venous and ethyl abuse, which was stopped 20 years before pulmonary thrombosis, unstable angina and admission. In order to perform right and left side non-ST-elevation myocardial infarction is widely cardiac catheterisation, oral anticoagulants were accepted. Nowadays, for many of these indications switched to nadroparin calcium (Fraxiparine®, Sathe unfractionated heparins (UFH; molecular weight nofi-Synthelabo, Brussels, Belgium)1 7.500U AXa [MW] 3–30 kDa) are largely being replaced by IC (Institut Choay) twice daily. Ten days after startlow-molecular-weight heparins (LMWHs; MW ≤5 ing this preservative-free LMWH he developed a kDa) because of the improved pharmacokinetic and large eczematous plaque (5 × 15cm) at the injection pharmacodynamic properties as well as a better site. There was neither thrombocytopenia nor eosisafety profile of the latter.[1-3] Adverse reactions to nophilia. The lesion subsided within 1 week after heparins include haemorrhages, osteopenia and imstopping the drug and application of a topical cortimune-mediated hypersensitivity reactions, e.g. costeroid. heparin-induced thrombocytopenia without and Investigations were performed in the patient and with (fatal) thrombosis,[4-10] immediate hypersensiin a healthy control who was free of any medication. tivity reactions such as rhinoconjunctivitis,[11] asthA lymphocyte transformation test (LTT) with ma,[12] urticaria, angio-oedema and anaphylaxnadroparin calcium assessed by the incorporation is,[12-25] and delayed cutaneous reactions generally of [methyl-3H] thymidine[36] was strongly positive manifesting as infiltrated, eczematous plaques or with a stimulation index, i.e. counts per minute leukocytoclastic vasculitis (type III Arthus reaction) (cpm) of the nadroparin calcium-stimulated lymat injection sites.[26-35] phocytes divided by the cpm cultured with serumfree medium, of 135 (normal <2). Flow cytometric 1. Case Report analysis of in vitro nadroparin calcium-activated A 47-year-old man with severe heart failure due basophils (BAT)[37] showed a CD63 upregulation to a dilated cardiomyopathy was admitted for carabove spontaneous expression of 63% (normal diac transplantation screening. His medical history <15%). Meanwhile, the patient was re-administered included pacemaker implantation because of a sick nadroparin calcium accidentally, which resulted in sinus syndrome with syncope, depression, osteoan immediate local erythematous eruption of several penia, gastritis, antral ulcers, a small biliary cyst and centimetres and a generalised pruritus and urticaria.