Hypersensitivity reactions to Proton Pump Inhibitors. An EAACI Position Paper

Alessandra Arcolaci,Alla Nakonechna,Patrizia Bonadonna,Marina Atanasković-Marković,Lombardo Carla,Knut Brockow,José Laguna,Mauro Pagani,María José Torres,Sevim Bavbek,Annick Barbaud,Seçil Kepil Özdemir

doi:10.22541/au.169820663.38630170/v1

Hypersensitivity reactions to Proton Pump Inhibitors. An EAACI Position Paper

Alessandra Arcolaci, Alla Nakonechna + Show 10 more

https://doi.org/10.22541/au.169820663.38630170/v1

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Publication Date: Oct 25, 2023

Affiliation: Azienda Ospedaliera Universitaria Integrata Verona, Lancashire Teaching Hospitals NHS Foundation Trust, Provincia Autonoma di Trento, EU Business School, Hospital Universitario HM Madrid, Azienda Socio Sanitaria Territoriale Lariana, Hospital Regional Universitario de Málaga, Ankara University, Pierre Louis Institute of Epidemiology and Public Health, Ankara Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Ve Araştırma Hastanesi

#Proton Pump Inhibitors #Proton Pump Inhibitors Consumption + Show 8 more

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Abstract

Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.

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