Hypersensitivity pneumonitis: application of a new diagnostic algorithm to a time series of the disease

Abstract

ABSTRACT Background The diagnostic criteria for Hypersensitivity pneumonitis (HP) have changed over time. Our aim is to apply a recent diagnostic algorithm to a historical series of patients diagnosed with HP to assess its distribution according to current diagnostic criteria and the diagnostic confidence achieved. Research design and methods Application to each patient the algorithm criteria. The diagnosis was HP (≥90%), provisional high (70–89%) or low confidence (51–69%) or non-HP (unlikely) (≤50%); or HP, provisional or non-HP, if they had lung biopsy. Results 129 patients [mean age 64 ± 12 years; 79 (61.2%) women] were included of which 16 (12.4%) were diagnosed on the basis of high clinical suspicion. After applying the algorithm, 106 patients (82.2%) could be evaluated and 83 (78.3%) had a diagnosis of HP or high confidence. Lung biopsy was able to establish a diagnosis of certainty in another 21 patients and a provisional diagnosis in 9 more [total, 113 (87.6%)]. The 16 patients without strict diagnostic criteria for HP had a low confidence diagnosis. A total of 56 lung biopsies (64.4%) could have been avoided according to the new guidelines. Conclusions The application of this algorithm achieves a high diagnostic yield in HP, significantly reducing the number of lung biopsies required.