Abstract
1. 1. Biopsy studies of immediate and delayed skin reactions to tobacco and saline control wheals were studied in 10 patients with thromboangiitis obliterans, one of migrating phlebitis, and one with acute coronary thrombosis. 2. 2. Eosinophiles, varying in numbers, were found in the histologic sections of the immediate urticarial wheals produced by the tobacco allergen in 6 of 8 cases of thromboangiitis obliterans and in one case of migrating phlebitis. 3. 3. The biopsies of 2 patients with thromboangiitis obliterans and one 37-year-old patient with coronary artery thrombosis, who developed delayed reactions, showed an acute dermatitis. 4. 4. The exciting rôle of tobacco in the 12 cases studied was corroborated clinically by arrest in the progress of symptoms following cessation in the use of tobacco. In one patient (Case 9) giving a delayed eczematous type of local reaction, a generalized eczema and exacerbation of the symptoms of thromboangiitis obliterans were induced by repeated subcutaneous injections of tobacco extract.
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