Abstract
Acute toxic reactions following the use of organic mercurials as diuretic agents have received considerable attention in recent publications.1The present report deals with an unusual response to these compounds used as diuretics in a case of advanced congestive heart failure. Experiments were performed which throw some light on possible factors that might be involved in the mechanism of this reaction. The observations on our patient cover about five years. REPORT OF CASE A. G., was an unmarried woman aged 27 when she came under observation. She had rheumatic heart disease, with decided enlargement of the heart, mitral stenosis and insufficiency, auricular fibrillation and an advanced grade of heart failure with congestion. She appeared to have been hypersensitive to a wide variety of foods which occasionally produced hives. Her history embraced the details commonly encountered in that of a patient with rheumatic heart disease, although there was no history
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