Abstract
The responsiveness of lung parenchymal strips isolated from actively sensitized guinea pigs to some selected autacoids (histamine, 5-hydroxytryptamine, bradykinin, and prostaglandins F2 alpha and l2) and autonomic drugs (acetylcholine, norepinephrine, methoxamine, and isoprenaline) was compared with that of strips from unsensitized animals. The concentration-response curves to the agonists, with the only exception of isoprenaline, in the sensitized group exhibited a left upward displacement (greater maximal effects and less effective concentration 50%) compared with those obtained in the unsensitized group. These results indicate the existence of a nonspecific increase in responsiveness of lung parenchymal strip isolated from sensitized animals.
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