Abstract
To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months. Pediatric Endocrine Clinic, Hasharon Hospital, Petah Tiqva, Israel. Thirteen girls with idiopathic central precocious puberty. Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 +/- 5.6 to 21.5 +/- 12.5 micrograms/L (mean +/- SD). The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.
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