Abstract
Cromakalim alone at 1 μM had no effect and at 10 μM hyperpolarized the rat aorta. The rat aorta was depolarized by KCl (20 mM), noradrenaline (0.3 μM) and 5-hydroxytryptamine (1 μM). In the presence of depolarization with KCl, noradrenaline or 5-hydroxytryptamine, cromakalim at 1 and 10 μM hyperpolarized the rat aorta. Thus the antispasmogenic actions of modest concentrations of cromakalim is compatible with potassium channel opening.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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