Abstract
PurposeTo develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. Materials and methodsHHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D–spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice. ResultsMotion-artifact–free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. ConclusionHHe ventilation MRI can aid assessment of pediatric lung disease even at a young age.
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