Abstract
In this review we describe the molecular structure of the hyperpolarization-activated cAMP-dependent Ih, or HCN, pacemaker channel. We discuss the channel functions and its subunit composition. Also, we hypothesize that spike-wave discharges in absence epilepsy are caused by these Ih channels located on the neurons of the thalamic reticular nucleus and layers three, four, and five of the somatosensory cortex. We describe the role of Ih channels on reticular and cortical neurons in normal behavior.
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