Abstract
1. 1. The effects of histamine on soluble calcium concentrations in gastrointestinal tract contents, acid secretion, urinary phosphorus excretion, plasma free-hydroxyproline and inorganic phosphorus levels were studied in laying hens during egg shell formation. 2. 2. Histamine induced hyperphosphataemia, hyperhydroxyprolinemia and decreased soluble gastro-intestinal calcium at 3 hr after injection. 3. 3. Cimeticline inhibited all effects induced by histamine. This suggests that hyperphosphataemia arises from increased bone resorption provoked by decreased soluble intestinal calcium during egg shell formation.
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