Abstract
Thirteen elderly male patients with measured cognitive deficits were treated with 30 intermittent exposures to 100 per cent oxygen at 2.5 atmospheres absolute. Five controls, each exposed at the same time and manner as a paired experimental patient, breathed a low oxygen mixture that maintained essentially normal alveolar oxygen tension despite increased ambient pressure. Arterial samples for blood gas determinations were obtained from each patient during one of the early hyperbaric exposures. Analysis showed the expected large intra-exposure increase in arterial oxygen tension among the experimental subjects. Negligible changes in arterial oxygen tension were found among control patients. Post-treatment performance on psychological tests of cognitive functioning showed highly significant gains over pretreatment levels in experimental subjects, suggesting an improved performance that persisted beyond the temporary increase in arterial oxygen tension levels. Control patients showed no improvement in post-treatment cognitive functioning.
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