Hypermetabolism in Patients With Dementia With Lewy Bodies

Abstract

Detection of hyperperfusion by I-123 N-isopropyl-p-iodoamphetamine single photon emission computed tomography can be helpful to diagnose dementia with Lewy bodies (DLB). This study characterized hypermetabolism in DLB. A total of 22 probable cases of DLB were examined by F-18 2-fluoro-2-deoxy-D-glucose positron emission tomography. Hypermetabolism was found in the peri-motor area, basal ganglia, and cerebellum. Eleven patients had hypermetabolism in all 3 areas, 6 in 2 areas, 4 in 1 area, and 1 in no area. Hypermetabolism was most frequent in the cerebellum. Comparison of the 11 patients with hypermetabolism in all 3 areas to the other 11 cases found no significant differences in age (P = 0.2555), sex (P = 0.1889), Mini-Mental State Examination score (P = 0.0897), and Parkinsonism. However, visual hallucinations were significantly more frequent in the patients with hypermetabolism in all 3 areas (P = 0.0018). Hypermetabolism is common in patients with DLB and may be related to visual hallucinations.