Abstract
Clinical indicators of birth asphysia were correlated with the concentrations of the 4 major cations in blood from 95 human placentas. The plasma concentration of Mg<sup>++</sup> was inversely related to the Apgar score, whereas the Na<sup>+</sup> and Ca<sup>++</sup> concentrations were not influenced by birth asphyxia. There was suggestive evidence for a rise in the plasma K<sup>+</sup> concentration with birth asphyxia. A series of experiments on newborn dogs confirmed that with acute neonatal anoxia there is a shift of the 2 major intracellular cations into the plasma.
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