Hypermagnesaemia, but Not Hypomagnesaemia, Is a Predictor of Inpatient Mortality in Critically Ill Children with Sepsis.

Huabin Wang,Yuhui Wu,Chun Chen,Chunmei Chen,Xinghan Jin,Junbin Huang,Airun Zhang,Carlo Chiarla

doi:10.1155/2022/3893653

Abstract

Objective The effect of serum magnesium on the prognosis of children with sepsis in the pediatric intensive care unit (PICU) is unclear. This study was designed to assess the risk of inpatient mortality for children with sepsis in the PICU based on serum magnesium levels at admission. Methods We collected patients' clinical information from the Pediatric Intensive Care database and then performed locally weighted scatterplot smoothing (LOWESS) analysis, Kaplan–Meier analysis, and multivariate logistic regression to determine the relationship between admission serum magnesium and inpatient mortality in children with sepsis. Results A total of 974 critically ill children with sepsis were included, with 246 patients in the hypomagnesemia group, 666 in the normal group, and 62 in the hypermagnesemia group. The chi-square test suggested that the hypermagnesemia group had higher in-hospital mortality than the normal group (14.5% vs. 2.4%, P < 0.001). Kaplan–Meier curves revealed that the 30-day overall survival rate was lower in the hypermagnesaemia group than in the normal group (P < 0.001). The multivariate logistic regression model revealed that hypermagnesaemia was a risk factor related to inpatient mortality (odds ratio 4.22, 95% CI 1.55-11.50), while hypomagnesaemia was not a significant factor for inpatient mortality (odds ratio 0.78, 95% CI 0.26-2.32). Conclusion Hypermagnesaemia, but not hypomagnesaemia, is a predictor of inpatient mortality in critically ill children with sepsis.

Highlights

Sepsis is caused by an imbalanced host response to infection and can lead to systemic multiorgan dysfunction
To our knowledge, no studies have investigated the relationship between serum magnesium and the prognosis of Disease Markers pediatric intensive care unit (PICU) patients with sepsis, and clinicians do not have simple indicators to assess the prognosis of children with sepsis
The normal group was compared with the hypomagnesaemia group and the hypermagnesaemia group separately

Summary

Introduction

Sepsis is caused by an imbalanced host response to infection and can lead to systemic multiorgan dysfunction. Among the 7.6 million children who die at ages younger than 5 years, 64% die of sepsis or septic shock caused by severe infection [1, 2]. Serum magnesium has attracted increasing attention from the medical community as a novel prognostic indicator. Several studies have shown that serum magnesium is related to an increased risk of acute respiratory failure, acute kidney injury, and shock [5–7]. To our knowledge, no studies have investigated the relationship between serum magnesium and the prognosis of Disease Markers pediatric intensive care unit (PICU) patients with sepsis, and clinicians do not have simple indicators to assess the prognosis of children with sepsis. The aim of this study was to investigate the value of serum magnesium for predicting mortality in children with sepsis

Methods

Results

Discussion

Conclusion