Abstract
Advances toward improving cardiovascular health of tomorrow's adults lie both in acknowledging that the pathogenesis of atherosclerosis begins in childhood and in considering the influence of environmental factors on genetic endowment of risk. Based on current understanding of lipoprotein transport processes, an array of genetic disorders with various degrees of atherogenicity can be classified according to the predominant lipoprotein density class, as represented by a standard lipid profile, and then further defined by assaying apolipoproteins and their receptors, lipoprotein transport enzymes, or the respective variant genes. Alternatively, a simple and potentially cost-effective representation of multifactorial influences on lipid transport is provided by an assessment of apolipoprotein particle composition using serial immunologic precipitation of apolipoproteins while on their intact plasma lipoproteins. A comprehensive intervention strategy can be based on identification of inherited risk and the effects of nongenetic factors, which include dietary excess, inactivity, disease states, and medications.
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