Abstract
Two patients with hyperlipemia and pancreatitis are described. Studies of post-heparin lipase showed an increased level in both cases. In 1 patient, with severe pancreatitis as indicated by a dramatic fall in calcium and development of a pancreatic cyst, there was an inhibitor of plasma lipoprotein lipase activity. In this study hyperlipemia as evidenced by the development of xanthomas appeared to precede the development of acute pancreatitis in both patients. The hyperlipemia improved when alcohol was stopped in 1 patient and a high carbohydrate diet was stopped in the other. In the first patient a lipoprotein lipase inhibitor was present, but the second patient did not have an inhibitor. In 1 case there was marked prolongation of the hyperlipemia which coincided with the presence of the lipoprotein lipase inhibitor. The inhibitor appeared to be a protein, and it is likely that it was released from necrotic pancreatic tissue. The patient with an inhibitor had a very marked rise in both cholesterol and triglyceride.
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