Abstract
Sir, Hyperkeratosis of the nipple and the areola (HNA) is a rare, benign condition characterized by asymptomatic hyperkeratosis and hyperpigmentation affecting the nipples and/or the areolae mammae (1 – 3). It may be idiopathic or associated with diseases such as ichthyosis, acanthosis nigricans, Darier’s disease or endocrinopathies. A few cases have also been reported related to internal malignancies, cutaneous T-cell lymphoma, or use of drugs (oestrogen and spironolactone) (4 – 7). We report here a case of HNA that developed during chronic cutaneous graft versus host disease (GVHD) following allogeneic peripheral blood stem cell transplantation.
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