Hyperintensities of middle frontal gyrus in patients with diabetic optic neuropathy: a dynamic amplitude of low-frequency fluctuation study.

Lin Yang,Yi Shao,Qiong Zhou,Wen-Qing Shi,San-Hua Xu,Ping Ying,Rong-Bin Liang,Hui-Feng Zhong,Ting Su,Ang Xiao,Qiu-Yu Li

doi:10.18632/aging.203877

Abstract

Diabetic optic neuropathy (DON) is a diverse complication of diabetes and its pathogenesis has not been fully elucidated. The purpose of this study was to explore dynamic cerebral activity changes in DON patients using dynamic amplitude of low-frequency fluctuation (dALFF). In total, 22 DON patients and 22 healthy controls were enrolled. The dALFF approach was used in all participants to investigate dynamic intrinsic brain activity differences between the two groups. Compared with HCs, DON patients exhibited significantly increased dALFF variability in the right middle frontal gyrus (P < 0.01). Conversely, DON patients exhibited obviously decreased dALFF variability in the right precuneus (P < 0.01). We also found that there were significant negative correlations between HADS scores and dALFF values of the right middle frontal gyrus in the DON patients (r = -0.6404, P <0.01 for anxiety and r = -0.6346, P <0.01 for depression; HADS, Hospital Anxiety and Depression Scale). Abnormal variability of dALFF was observed in specific areas of the cerebrum in DON patients, which may contribute to distinguishing patients with DON from HCs and a better understanding of DON, hyperintensities of right middle frontal gyrus may be potential diagnostic marker for DON.

Highlights

Diabetes mellitus (DM) is a common chronic disease and its prevalence continues to increase [1]
The individual area under ROC curve (AUC) of altered dynamic amplitude of low-frequency fluctuation (dALFF) values were as follows: Diabetic optic neuropathy (DON) >health controls (HCs), middle frontal gyrus (MFG_R) (0.997, P < 0.0001, 95% CI: 0.985–1.000; Figure 3A); DON
These results indicated that dALFF values in altered brain areas may be helpful in diagnosing DON

Summary

Introduction

Diabetes mellitus (DM) is a common chronic disease and its prevalence continues to increase [1]. With progression of DM, neuropathy has become the most common symptomatic complication of diabetic patients [2]. Diabetic optic neuropathy (DON) is one of the major chronic complications of DM [3], and includes diabetic papillopathy, optic disc neovascularization, nonarthritic anterior ischemic optic neuropathy and optic atrophy [4]. The prevalence of DON in diabetic retinopathy (DR) patients is 38.4% [5]. Hyperglycemia in diabetic patients decreases local tissue blood flow and this could affect the metabolism of the optic nerve [6]. There is irreversible atrophy of the optic nerve as the disease progresses over time, which eventually leads to blindness

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