Abstract
To the Editor. —I read with great interest the article by Facchini et al, 1 which correlated uric acid clearance with insulin resistance. Such an explanation fits with earlier studies in which the administration of antilipemic doses of nicotinic acid induced hyperglycemia, abnormal glucose tolerance, hyperinsulinemia, hyperuricemia, and apparent decreases in the renal clearance of uric acid. 2-5 At that time, nicotinic acid and/or one or more metabolites thereof were postulated to reduce the renal excretion of uric acid. In light of the Facchini study, changes in uric acid metabolism may have been induced by renal effects of the concomitant hyperinsulinemia. This letter was shown to the author, who declined to reply. —Ed.
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