Abstract
To the Editor. —I read with great interest the article by Facchini et al, 1 which correlated uric acid clearance with insulin resistance. Such an explanation fits with earlier studies in which the administration of antilipemic doses of nicotinic acid induced hyperglycemia, abnormal glucose tolerance, hyperinsulinemia, hyperuricemia, and apparent decreases in the renal clearance of uric acid. 2-5 At that time, nicotinic acid and/or one or more metabolites thereof were postulated to reduce the renal excretion of uric acid. In light of the Facchini study, changes in uric acid metabolism may have been induced by renal effects of the concomitant hyperinsulinemia. This letter was shown to the author, who declined to reply. —Ed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.