Abstract
Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood. To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. Comparative study of 21 obese children with a body mass index (BMI) over percentile 95, aged 10 ± 1 years (10 males), 14 children aged 10 ± 2 (7 males) with a BMI between percentiles 85 and 94 and 16 children aged 9 ± 2 years (3 males) with a body mass index between percentiles 10 and 84. Body weight, blood pressure and waist circumference were measured and a blood sample was obtained to measure fasting glucose and insulin levels. Homeostasis model of insulin resistance (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated. Among obese, overweight and normal weight children, insulin levels were 14.9 (95% CI 10.90-18.99), 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively. The figures for HOMA were 3.16 (95% CI 2.20-4.12), 1.49 (95% CI 1.03-1.94) and 0.97 (95% CI 0.35-1.60), respectively. The figures for QUICKI were 0.331 (95% CI 0.319-0.343), 0.371 (95% CI 0.349-0.393) and 0.419 (95% CI 0.391-0.446), respectively. Compared to their normal weight counterparts, the risk of obese children and those with a waist circumference over percentile 90 of having a HOMA over 3.16 was 17 and 10 times higher, respectively. BMI correlated better than waist circumference with insulin levels. Obese children have higher levels of insulin resistance than their normal weight counterparts.
Highlights
Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood
Among obese, overweight and normal weight children, insulin levels were 14.9, 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively
Results: Among obese, overweight and normal weight children, insulin levels were 14.9 (95% CI 10.90-18.99), 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively
Summary
Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood. Compared to their normal weight counterparts, the risk of obese children and those with a waist circumference over percentile 90 of having a HOMA over 3.16 was 17 and 10 times higher, respectively. El propósito del estudio fue estimar valores de insulina y marcadores de RI en niños de dos escuelas públicas de Oaxaca, México, y determinar la probabilidad de hiperinsulinemia y RI. Se consideró obesidad abdominal la CC por arriba de percentil 90 de acuerdo a sexo y edad, en base a las gráficas para niños México-Americanos[20]. Características epidemiológicas de los niños del estudio de hiperinsulinemia y resistencia a la insulina en niños en Oaxaca, México
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