Abstract
Hyperinflammation, T cells, and endotoxemia.
Highlights
Inhibition of unleashed innate immune responses by T cells was first reported by Kim et al [1]
First critical finding for us was that adoptive transfer of total T cells from naïve mice successfully improved survival of Rag2-/- mice from endotoxemia by decreasing systemic tumor necrosis factor (TNF) levels [3]
Naïve T cells inhibited TNF production by LPS-treated macrophages without any cognate antigens in tissue culture; and the function was demonstrated in 24 hours, which is too early for T cell activation [3]
Summary
Inhibition of unleashed innate immune responses by T cells was first reported by Kim et al [1]. First critical finding for us was that adoptive transfer of total T cells from naïve mice successfully improved survival of Rag2-/- mice (mice lacking T and B cells) from endotoxemia by decreasing systemic TNF levels [3]. Naïve T cells inhibited TNF production by LPS-treated macrophages without any cognate antigens in tissue culture; and the function was demonstrated in 24 hours, which is too early for T cell activation [3]. Direct contact between T cells and macrophages was essential for the T cell-mediated inhibitory function [3].
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