Abstract
To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intragastrication of hyperin. Twenty-four hours later, blood and liver were collected for further research. A single injection of cisplatin (40 mg/kg) for 24 h significantly increased serum alanine and aspartate aminotransferases (ALT/AST) and gamma glutamyl transferase (GGT) activities, whileas hyperin reversed cisplatin-induced such increases. Liver histopathological examination further demonstrated the protection of hyperin against cisplatin-induced liver injury. Further results showed hyperin reversed cisplatin-induced the increase in content of malondialdehyde (MDA) and the decrease in level of total antioxidant capacity (T-AOC) in liver. Moreover, hyperin increased the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s transferase (GST) in cisplatin-induced liver. Hyperin inhibits cisplatin-induced hepatic oxidative stress, which contributes greatly to the amelioration of cisplatin-induced liver injury in mice.
Highlights
IntroductionIn spite of the benefits available, it is accompanied with potent side effects
Chemotherapy plays an important role in the treatment of cancer nowadays
The dose selection was based on the literatures[16,20,21] and our preliminary experiment. 24 hours later, blood samples were collected by extirpating the eyeball, approximately 0.8 ml per mice, and mice were sacrificed, their livers were removed for further research
Summary
In spite of the benefits available, it is accompanied with potent side effects. The severe reactions of chemotherapeutic agents are a major limitation to the use of drug in the clinic[1]. Cisplatin is a potent chemotherapeutic agent used for the treatment of a wide range of cancer such as ovarian, cervical, and head and neck cancers[2,3]. Cisplatin therapy brings about undesirable side effects, including renal dysfunction[4], ototoxicity[5], nausea and vomiting[6], and hepatotoxicity[7]. Hepatotoxicity is not considered to be a dose limiting toxicity for cisplatin, but liver toxicity can occur when it is administered at high doses[8], which has been an obstacle for the further usage of cisplatin
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