Abstract
BackgroundTo investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China.MethodsWe performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54 ± 10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level > 15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS.ResultsThe left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23 ± 16.34 vs. 40.09 ± 10.55 g-2.7, P < 0.001; males: 48.67 ± 12.24 g-2.7 vs. 42.42 ± 11.38 g-2.7, P < 0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58 ± 31.92 g− 2 vs. 86.63 ± 20.47 g− 2, P < 0.001; males: 106.10 ± 24.69 g− 2 vs. 98.16 ± 23.29 g− 2, P < 0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P < 0.001, OR: 2.433 for LVMH2.7, P < 0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P < 0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P < 0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH.ConclusionHyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.
Highlights
To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China
In the present study, we found that HHcy alone was associated with a higher risk of LVH in rural Northeast China
We found that HHcy alone could increase the risk of LVH in the general population of rural Northeast Chinese residents, which agrees with many other previous studies
Summary
To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Hyperhomocysteinemia has been reported to be relevant in cardiovascular diseases linked to atherosclerosis and is considered an independent marker of many cardiovascular risk factors [1]. Zhao and colleagues claimed that the combination of hyperhomocysteinemia and hyperuricemia could result in accelerated atherosclerosis [2]. Zhang and colleagues confirmed that the coexistence of hyper-homocysteinemia and elevated blood. LVH has already been confirmed to be independently correlated with the deterioration of health and increased risk of cardiovascular death. LVH statistically increases the risks of myocardial infarction, dysfunctions of the heart, stroke and sudden cardiac death [5]. One study claimed that homocysteine levels are explicitly associated with cardiac systolic function in subjects with coronary artery disease (CAD) [6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
