HYPERGONADOTROPIC OVARIAN INSUFFICIENCY IN WOMEN OF LATE REPRODUCTIVE AGE

Abstract

Background. At present, the increasing frequency of hypergonadotropic ovarian insufficiency in women of late reproductive periods is associated with various problems, which requires the development of new criteria and an integrated approach to solving these problems. Aim of the study. To investigate the causes, clinical manifestations and diagnostic criteria of hypergonadotropic ovarian insufficiency in women of late reproductive age. Materials and methods. We examined 42 patients with clinical and laboratory criteria for hypergonadotropic ovarian failure. The causes and clinical manifestations of hypergonadotropism, as related to ovarian failure, in women of late reproductive age were revealed through this analysis. Results. Women aged 36 – 42 years that have had previous surgery on pelvic organs often undergo changes typical of hypergonadotropism. Certain clinical indicators such as lability of follicle-stimulating hormone (FSH) levels and other direct and indirect signs of decreased ovarian reserves allow practitioners to prescribe appropriate therapy on time. Timely diagnosis and an individualized approach can help prevent symptoms of hypoestrogenia and related complications. The results of this study show that early detection of a luteal out-of-phase (LOOP) event, along with a more detailed history was diagnosed in 16 (38.1%) of cases. Early detection allows more timely changes in diagnosis, may noted signs that can reflect both the normal state and pathology. Conclusions. Levels of Anti-Müllerian hormone, basal levels of FSH in two successive cycles, early detection of an LOOP-event and the use of ultrasound are significant factors that can help in the assessment of ovarian reserves.