Abstract
Spinal cord injury (SCI) is a major public health problem and a devastating event for individuals. Because the central nervous system has a limited capacity for endogenous regeneration and repair, it is necessary to identify factors that exacerbate SCI to prevent any further deterioration of neurological function and improve the outcomes of injuries[1]. We previously demonstrated that transient hyperglycemia during acute SCI is a detrimental factor that impairs functional improvement in mice and human patients after acute SCI[2]. Although we performed not only Pearson x2 analysis but also a multiple linear regression analysis in the previous study, neurological function is difficult to be assessed for the patients with multiple injury levels. It is more ideal to estimate neurological recovery after SCI to match the injury level.
Highlights
Spinal cord injury (SCI) is a major public health problem and a devastating event for individuals
To assess whether hyperglycemia purely affects neurologic outcomes of the patients with the same injury level, in this study, we selected acute C3-C4 cervical cord injury patients without any bony damages, which is most popular SCI in Japan
We examined the relationships between the admission blood glucose concentration values and other functional/clinical measurements, including American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade, and the total spinal cord independence measure (SCIM) scores at the final follow-up
Summary
Spinal cord injury (SCI) is a major public health problem and a devastating event for individuals. Objective To clarify the effects of hyperglycemia on the functional outcomes after SCI.
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