Abstract
This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the diversion of stem cells to pathological adipocytes when they divide in hyperglycemia.
Highlights
This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue
We have shown that rat bone marrow stromal cells stimulated to divide in osteogenic medium in which the glucose concentration was increased from normal (5 mM) to hyperglycemic (25 mM) diverted to a pathological adipogenesis [2]
The hyaluronan synthase (HAS) enzymes normally migrate to the plasma membrane before activation, and the elongating, polyanionic, very large hyaluronan macromolecules are extruded into the extracellular pericellular matrix
Summary
This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. Our studies and others provide clues for the mechanisms involved. We have shown that rat bone marrow stromal (stem) cells stimulated to divide in osteogenic medium in which the glucose concentration was increased from normal (5 mM) to hyperglycemic (25 mM) diverted to a pathological adipogenesis [2].
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