Abstract
Purpose : To evaluate the effect of shortening overall treatment time by hyperfractionated-accelerated radiotherapy for T 2N 0M 0 glottic carcinomas. Results for local control and survival were calculated and compared to those for T 1N 0M 0 tumors treated with a once-a-day fractionated schedule. Methods and Materials : Between 1990 and 1998, 92 patients with T 1N 0M 0 and 45 patients with T 2N 0M 0 glottic cancers were treated with radical radiotherapy. The T 1N 0M 0 tumors were treated with a once-a-day fractionated schedule lasting 6.5 weeks to a total dose of 62.4 Gy. The T 2N 0M 0 tumors received a split-course hyperfractionated-accelerated treatment over a total of 4.5 weeks to a total dose of 64.6 Gy. Results : The 5-year local control was 85% for T 1N 0M 0 and 88% for T 2N 0M 0, whereas the 5-year locoregional control was 85% for both groups. The 5-year overall survival was 70% and 53% for T 1N 0M 0 and T 2N 0M 0, respectively. No significant statistical difference was found between the two groups for the parameters analyzed. The number of serious late complications was few and comparable for the two groups. Conclusions : Hyperfractionated-accelerated radiotherapy proved beneficial for T 2N 0M 0 glottic cancer, giving local control rates comparable to those for T 1N 0M 0 tumors.
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