Abstract
ABSTARCT The aim of this study wa s to evaluate the hyper excitability caused b y administration of F luoxetine which is a highly prescribed anti depressan t belonging to a Selective Serotonin Reuptake I nhibitor class . Behavioral activities were observed on Cage Crossing, Forced Swim Test, Open Field Test and Head Dip T est. These activities were observed on rodents after 60 days of oral Fluoxetine tr eatment and were compared with untreated control animals . The results clearly showed that Fluoxetine caused significant incr ease in number of head dips in head dip test, significant increase in number of cage crosses in cage crossing, significant increase in number of squares crossed in an open field apparatus and significant increase in struggling time in forced swim test. Thus overall results indicated hyper excitability in treated animal s. Hence, outcomes suggest that Fluoxetine can lead to hyper excitat ion in behavior and produce anxiety and therefore strongly implies that Fluoxetine use may also require an anxiolytic drug to antagonize this hyper excitability .
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