Abstract
1.1. Postmenopausal hyperestrinism may be associated morphologically with hyperplasia and production of new cells of endocrine type in the ovaries.2.2. These cells, luteinized stromal cells and hilus (Leydig) cells, may be the manufacturers of estrogens in the postmenopausal ovary.3.3. The lutein cell nests may involute with the formation of scars.4.4. It is possible that the adrenal cortex can participate with the ovaries in the production of postmenopausal hyperestrinism, and that both glands are stimulated by the anterior pituitary in such cases.5.5. A case has been presented in which endometrial carcinoma and a pronounced estrogen effect in the vaginal smear of a 73-year-old woman were associated with ovarian cortical and medullary hyperplasia, production of luteinized stromal and hilus cells, and possible adrenal hyperactivity.
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