Abstract
BackgroundWhen increased serum cobalamin concentrations are encountered clinically they are usually attributed to parenteral supplementation, dietary factors, or otherwise ignored. However, recently, hypercobalaminaemia has been associated with numerous diseases in humans, most notably neoplastic and hepatic disorders. The aim of this retrospective, observational, cross-sectional study was to determine the significance of increased cobalamin in cats.ResultsIn total, 237 records were retrieved and 174 cats, of various ages and sexes met the inclusion criteria. A total of 42 cats had increased serum cobalamin concentration, and had not received prior supplementation. Multiple logistic regression analysis revealed that increased serum cobalamin concentration was positively related to pedigree breed (pedigree breeds more likely to have increased cobalamin concentration, odds ratio [OR] 4.24, 95% CI 1.78-10.15, P = 0.001), to having liver disease (OR 9.91, 95% CI 3.54-27.68), and to having a solid neoplasm (OR 8.54, 95% CI 1.10-66.45).ConclusionsThe results of the current study suggest that increased serum cobalamin concentrations should not be ignored in cats with no history of supplementation, and investigation for underlying hepatic or neoplastic disease is warranted.
Highlights
When increased serum cobalamin concentrations are encountered clinically they are usually attributed to parenteral supplementation, dietary factors, or otherwise ignored
Hypocobalaminaemia has been reported in cats with gastrointestinal disease [3,4], exocrine pancreatic insufficiency [5] and hyperthyroidism [6]
Hypercobalaminaemia is associated with myeloproliferative disorders [10,11,12] and with a wide range of solid neoplasms including liver, mammary, prostatic, pulmonary, gastric and pancreatic tumours [9,13]
Summary
When increased serum cobalamin concentrations are encountered clinically they are usually attributed to parenteral supplementation, dietary factors, or otherwise ignored. Hypercobalaminaemia has been associated with numerous diseases in humans, most notably neoplastic and hepatic disorders The aim of this retrospective, observational, cross-sectional study was to determine the significance of increased cobalamin in cats. Hypercobalaminaemia is associated with myeloproliferative disorders [10,11,12] and with a wide range of solid neoplasms including liver, mammary, prostatic, pulmonary, gastric and pancreatic tumours [9,13]. It has, been suggested to be a nonspecific marker for cancer [13]. The aim of this study was to determine whether disease associations exist for hypercobalaminaemia in cats
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