Abstract
Meeting Abstracts1 May 1970Hypercalcemic Response to Hydrochlorothiazide in Uremia: Evidence for an Extrarenal Effect on Calcium Metabolism.M. H. Koppel, (Associate), J. H. Shinaberger, M.D., S. G. Massry, M.D., M. Popovtzer, M.D., J. W. Coburn, M.D., F.A.C.P.M. H. Koppel, (Associate)Search for more papers by this author, J. H. Shinaberger, M.D.Search for more papers by this author, S. G. Massry, M.D.Search for more papers by this author, M. Popovtzer, M.D.Search for more papers by this author, J. W. Coburn, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-803_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThiazides may decrease urinary calcium, and in primary hyperparathyroidism such drugs may aggravate hypercalcemia, presumably because of reduced renal excretion of calcium. We have observed hypercalcemia during thiazide therapy in three uremic patients with clinically overt secondary hyperparathyroidism; serum calcium levels fell upon cessation of thiazide therapy. To further evaluate this phenomenon, studies were undertaken in 14 uremic patients undergoing maintenance hemodialysis. Hydrochlorothiazide, 200 mg/day, was given orally for 2 to 4 weeks; calcium was measured in predialysis and postdialysis blood samples, obtained twice weekly, before (control period), during, and after thiazide therapy. Serum calcium rose to levels above the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byShort term effects and urinary excretion of the new diuretic, indapamide, in normal subjects 1 May 1970Volume 72, Issue 5Page: 803-803KeywordsBloodCalciumDrugsExcretionHypercalcemiaHyperparathyroidism Issue Published: 1 May 1970 PDF downloadLoading ...
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