Abstract
Humoral Hypercalcemia of Malignancy (HHM) has been reported in association with a number of malignancies. In gynecologic malignancies, ovarian Clear Cell Carcinoma (CCC) is one of the most commonhistologic subtypes, whereas HHM caused by endometrial CCC is very rare. We report a case of endometrial CCC with HHM, with a low serum intact PTH level, elevated serum PTH-related Peptide (PTH-rP), and immunohistochemically demonstrated PTH-rP in the neoplasm.
Highlights
Hypercalcemia accompanied by malignancy is a common metabolic complication of malignancies and categorized into two major groups: one is Local Osteolytic Hypercalcemia (LOH), due to local osteolysis induced by the tumor metastasized to bone, while the other is Humoral Hypercalcemia of Malignancy (HHM), due to systemic bone resorption caused by Parathyroid Hormone-related Protein (PTHrP)
HHM caused by endometrial cancer is even rarer and only a few cases of paraneoplastic hypercalcemia associated with endometrial cancer have been reported previously [2]-[5]
We report a case of endometrioid clear cell adenocarcinoma of the uterine corpus associated with HHM prior to the primary surgery and proved immunohistochemically that
Summary
Hypercalcemia accompanied by malignancy is a common metabolic complication of malignancies and categorized into two major groups: one is Local Osteolytic Hypercalcemia (LOH), due to local osteolysis induced by the tumor metastasized to bone, while the other is Humoral Hypercalcemia of Malignancy (HHM), due to systemic bone resorption caused by Parathyroid Hormone-related Protein (PTHrP). HHM caused by endometrial cancer is even rarer and only a few cases of paraneoplastic hypercalcemia associated with endometrial cancer have been reported previously [2]-[5]. We report a case of endometrioid clear cell adenocarcinoma of the uterine corpus associated with HHM prior to the primary surgery and proved immunohistochemically that. (2016) Hypercalcemia Due to Parathyroid Hormone-Related Protein Induced by Primary Endometrial Clear Cell Adenocarcinoma: Case Report.
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