Abstract
The synthesis of hyperbranched aminobisphosphonic acid polymers via reversible addition-fragmentation chain transfer (RAFT) self-condensing vinyl polymerization is reported. A novel acrylamide-functional chain transfer monomer is synthesized and characterized by 1 H and 13 C NMR spectroscopy, elemental analysis, and mass spectrometry. The monomer is subsequently copolymerized with an acrylamide monomer bearing a pendent amine group to create hyperbranched amine-functional polymers with degrees of branching dictated by changing the reaction stoichiometry. The aminobisphosphonate functional group is introduced via a 3-component Kabachnik-Fields reaction. An alternate functionalization of the amine polymers to create acid-degradable imine hydrogels is also employed. This work demonstrates the application of multicomponent reactions to RAFT-derived hyperbranched polymers and provides a new route to previously inaccessible polymers.
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