Abstract
An outbreak of hyperbilirubinemia occurred in cultured eel and diseased fish were macroscopically distinguished by yellowish surface discoloration of the abdomen and fins. Their livers exhibited many minute white spots and congestion; their total bilirubin levels were 4.6-14.2mg/100 ml, approximately 30 times higher than normal. Direct reacting bilirubin was 70.3-80.8% of total bilirubin. GOT and GPT levels were 73-304 and 12-37 Karmen units, respectively, approximately 4 times higher than normal. No significant difference in alkaline phosphatase activity was noted between normal and the diseased eels. The present hyperbilirubinemia was categorized as predominant type of conjugated bilirubin, associated with multifunctional liver cell impairment.
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