Abstract
Cerebral small vessel disease (CSVD) is a disease that encompasses many abnormalities relating to small blood vessels in the brain. Resting-state functional connectivity magnetic resonance imaging(rsfMRI) measures brain activity while subjects are not performing a task. The pathological basis for CSVD is thought in part to be due to reduced oxygen transport in the brain. In this study, we evaluated patients with CSVD before and after hyperbaric oxygen therapy(HBO) using rsfMRI of the default mode, dorsal attention, salience, fronto-parietal control, and somatomotor networks. We found that HBO therapy improved functional connectivity in the fronto-parietal control network and peripheral visual network. Further studies are needed to assess the long term benefit of HBO therapy. Support or Funding Information Amgen Foundation Poster This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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