Abstract
Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size. We hope that our concerns will be helpful for future clinical studies of HBO therapy in TBI or other neurological disorders.
Highlights
Hyperbaric oxygen therapy for Post concussion Symptoms: issues may affect the results Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury patients [1]
In these four prospective, randomized studies, the subjects were U.S military service members, and received 30 to 40 sessions of either a sham or hyperbaric oxygen (HBO) (1.5–2.4 Atmospheres absolute (ATA), 60 min once daily) in the treatment of PCS after mild Traumatic brain injury (TBI); and the outcome was primarily assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ)
We want to discuss these limitations, and hope that our concerns will be helpful for future clinical studies of Hyperbaric oxygen therapy (HBOT) in TBI or other neurological disorders
Summary
Hyperbaric oxygen therapy for Post concussion Symptoms: issues may affect the results Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients [1]. Hyperbaric oxygen therapy (HBOT) is an effective method for treating acute and severe TBI [2], effects of HBOT in the treatment of PCS has not been well established.
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