Abstract
Platelet aggregability was measured using platelet rich plasma collected from 197 clinical cases including 52 healthy volunteers. In the acute stage of thrombosis, a significant enhancement of platelet aggregation measured 5 min after an addition of 3 and 10 μM ADP or 0.1 and 1 μg/ml of adrenaline to PRP (p<0.05, compared to the healthy group). The enhancement was marked in the response induced by adrenaline. Such an enhancement was not observed in patients in the recovery stage of thrombosis, hypertension, angina pectoris and other miscellaneous diseases. There was no difference in the parameters related to the velocity of aggregation or intensity of primary aggregation between the diseased and the healthy group. In response induced by collagen any difference was not observed. There was a negative correlationship (r=−0.567, p<0.01) between the intensity of secondary aggregation by ADP and cyclic GMP phosphodiesterase activity of platelets.
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