Abstract
The anterior hippocampus in early psychosis or schizophrenia is hyperactive compared to controls. In rodent models, the ventral hippocampus (vHPC), analogous to the human anterior HPC, is also hyperactive. How anterior HPC hyperactivity influences intrahippocampal function across the structure’s longitudinal axis is unknown, an important question to understand why cognitive deficits in schizophrenia involve both anterior and posterior HPC function. We hypothesized that hyperactivity of ventral HPC mossy cells (MCs), which send longitudinal projections within the HPC, disrupts spatial memory encoding, a dorsal HPC (dHPC)-dependent function.
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