Hymodynamics study with rats of portal vein arterialization after extended hepatectomy

Abstract

Ojective To investigate the effects of portal vein arterialization(PVA) associated with portacaval shunt after extended hepatectomy on hepatic hemodynamics. Methods One hundred and thirty Sprague-Dawley rats were randomly assigned to three groups. Group A(PVA group), PVA associated with portocaval shunt after 70% PH; Group B(PH group),70% PH associated with right nephrectomy; Group C(control group), right nephrectomy only. The success rate of operation was and calculated, the pressure, diameter, blood flow velocity and inflow blood of portal vein were investigated at day 2, 7, 14, 28 days after operation, respectively. Results The success rate of operation in Group A, B and Group C were 85.1%, 93% and 100%, respectively. There was no significant difference between Group A and B. In Group A, the pressure, diameter, blood flow velocity and blood inflow of portal vein increased significantly and kept a stable higher level after surgery compared with the other two groups, P<0.01. The portal vein pressure reached the peak at postoperative 2 days and fell slowly with the passage of time, then remained stably 14 days after surgery in Group A. From postoperative 14 to 28 days, the blood inflow of portal vein in Group B were higher than Group C, P<0.05. And blood flow velocity in Group B was always faster than Group C after surgery. Conclusion The risk of PVA associated with portocaval shunt after extended hepatectomy procedure is not increased, the hymodynamics of the portal vein achieve a new balance at a higher level in 2 days and kept stable within 28 days after surgery. Key words: Hepatectomy; Portal Vein Arterialization; Portal vein pressure; Hemodynamics