HYGIENIC RISK ASSESSMENT OF ETOFENPROX-BASED INSECTICIDES USAGE FOR HUMANS BY TOXICITY PARAMETERS

Abstract

Background. As of 2023, 135 pyrethroid-based insecticides have been registered in Ukraine. The Ukrainian pesticide market offers products based on the new active ingredient etofenprox. According to the current legislation, the acceptable daily intake (ADI) of the new active ingredient etofenprox must be substantiated at the pre-registration stage.
 Aim: hygienic assessment of the toxic properties of the third-generation pyrethroid substance etofenprox and justification of the ADI of etofenprox, the active ingredient of the insecticide Trebon. Potential risk assessment for the workers and the general population. Determining the necessity of monitoring on environmental objects.
 Materials and methods. In the course of the work expert analysis, toxicological and hygienic research methods have been used.
 Results. It has been proven that etofenprox, in accordance with Sanitary Rules and Standards (SanPiN) 8.8.1.002-98, is of low danger – for oral and percutaneous ingestion and for allergenic effects, dangerous – for inhalation, moderately dangerous – for irritating effects on the skin and mucous membranes of the eyes. Integral hazard class - II (Limitation criteria - inhalation toxicity).
 The value of the ADI was estimated at the level of 0.003 mg/kg, based on toxicity data for mice in a chronic experiment and hazard class III for reproductive toxicity, embryotoxicity, teratogenicity (3.1 mg/kg is the lowest dose), factor of safety 1000 has also been considered.
 Conclusion. There has been established the necessity to consider the toxicity data of etofenprox when deciding on the need to perform monitoring studies of the content of etofenprox in water, soil, air, and agricultural raw materials.