Abstract
Introduction. There is continued trend in recent years of increasing the use of new chemicals, most of which are potential sources of risk to human health. The hygienic assessment of their application in the regions of the Russian Federation using various technologies is becoming more and more relevant. The aim of the work was to determine the exposure levels of mankoceb, tiram and metiram (pesticides of the dithiacarbamate group), to establish the threshold of the acceptable risk of exposure to pesticides for workers while complying with technical recommendations and safety requirements. Materials and methods. The determinations of the mancozeb, thiram and metiram were carried out by the gas-liquid chromatography with a flame-photometric detector (GC, FPD); the risk assessment was carried out by exposure (KBsumm) and absorbed dose (KBp) with a complex intake of active ingredients into the body of workers, under the Methodological Instructions № 1.2.3017-12. Results. There were analyzed more than 350 samples of air of the working zone and washing from workers’ skin. There was shown an absence of active substances mancozeb and metiram in them. The insignificant content of thiram at a level close to the limit of its quantitative determination was found. Conclusion. The results obtained allow assessing the risk of safe use of drugs based on dithiocarbamates in agriculture, which is the basis for predicting the total chemical exposure to humans, and accurately evaluating the levels of pollutants.
Highlights
There is continued trend in recent years of increasing the use of new chemicals, most of which are potential sources of risk to human health
There were analyzed more than 350 samples of air of the working zone and washing from workers’ skin
The results obtained allow assessing the risk of safe use of drugs based on dithiocarbamates in agriculture, which is the basis for predicting the total chemical exposure to humans, and accurately evaluating the levels of pollutants
Summary
Ларькина М.В., Михеева Е.Н., Федорова С.Г., Бондарева Л.Г. Тирама и метирама использован метод газожидкостной хроматографии с пламенно-фотометрическим детектором; оценку риска проводили по экспозиции (КБсумм) и поглощённой дозе (КБп) при комплексном поступлении действующих веществ в организм работающих в соответствии с Методическими указаниями МУ 1.2.3017-12. В результате анализа более 350 проб воздушной среды в рабочей зоне и смывов с открытых поверхностей кожи работающих установлено отсутствие в них действующих веществ манкоцеба и метирама и незначительное содержание тирама на уровне, близком к пределу его количественного определения. Полученные результаты позволяют оценить риск безопасного применения препаратов на основе дитиокарбаматов в сельском хозяйств в рекомендуемых технологических режимах обработки, что является основой при прогнозировании общего химического воздействия на человека, точной оценки уровней загрязняющих веществ. Для цитирования: Ларькина М.В., Михеева Е.Н., Федорова С.Г., Бондарева Л.Г. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Mytishchi, 141014, Russian Federation
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