Abstract
Chinese hamster ovary cells, selected in mitosis and plated into medium containing hydroxyurea, can progress through G 1 and enter S phase although bulk DNA synthesis is prevented. As the cells progress through G 1 in the presence of hydroxyurea, ornithine decarboxylase activity remains low while general protein synthesis appears unaffected. After hydroxyurea is removed, ornithine decarboxylase activity increases, but only after approximately 20% of the DNA has been replicated. These results suggest that ornithine decarboxylase induction is not essential for cellular progression into S phase but is required for the completion of DNA synthesis.
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