Abstract
American Journal of HematologyVolume 85, Issue 6 p. 401-402 CommentaryFree Access Hydroxyurea in sickle cell disease: What will it take to change practice?† George F. Atweh, Corresponding Author George F. Atweh [email protected] Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, OhioDivision of Hematology/Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670562, Cincinnati, OH 45267-0562Search for more papers by this author George F. Atweh, Corresponding Author George F. Atweh [email protected] Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, OhioDivision of Hematology/Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670562, Cincinnati, OH 45267-0562Search for more papers by this author First published: 13 April 2010 https://doi.org/10.1002/ajh.21733Citations: 1 † Conflict of interest: Nothing to report. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 D eSimone J, Heller P, Hall L, Zwiers D. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci USA 1982; 79: 4428– 4431. 2 Ley TJ, DeSimone J, Anagnou NP, et al. 5-Azacytidine selectively increases gamma-globin synthesis in a patient with beta1 thalassemia. N Engl J Med 1982; 307: 1469– 1475. 3 Ley TJ, DeSimone J, Noguchi CT, et al. 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood 1983; 62: 370– 380. 4 Letvin NL, Linch DC, Beardsley GP, et al. Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. N Engl J Med 1984; 310: 869– 873. 5 Charache S, Dover GJ, Moyer MA, Moore JW. Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 1987; 69: 109– 116. 6 Platt OS, Orkin SH, Dover G, et al. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 1984; 74: 652– 656. 7 Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 1995; 332: 1317– 1322. 8 Steinberg MH, Barton F, Castro O, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: Risks and benefits up to 9 years of treatment. JAMA 2003; 289: 1645– 1651. 9 Steinberg MH, McCarthy WF, Castro O, et al. The risks and benefits of longterm use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. Am J Hematol, in press; DOI: 10.1002/ajh.21699. Citing Literature Volume85, Issue6June 2010Pages 401-402 ReferencesRelatedInformation
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