Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia.

Jorge A. Ramírez-Tejero,Eva Siles,María Luisa del Moral,M Ángeles Peinado,Esther Martínez-Lara

doi:10.3390/nu12082386

Abstract

Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritional relevant dose of HT. Our results unveiled that fibroblast from FM show a differential expression in proteins involved in the turnover of extracellular matrix and oxidative metabolism that could explain the inflammatory status of these patients. Moreover, a number of these proteins results normalized by the treatment with HT. In conclusion, our results support that an HT-enriched diet could be highly beneficial in the management of FM.

Highlights

Fibromyalgia (FM) is a chronic syndrome whose main symptom is the widespread pain caused by both allodynia and hyperalgesia [1]
We compared the proteomes of fibroblasts from the healthy volunteer and from the FM patient
Our results unveiled that fibroblast from FM showed a differential expression in proteins involved in the turnover of extracellular matrix (ECM) and oxidative metabolism that could explain the inflammatory status of these patients

Summary

Introduction

Fibromyalgia (FM) is a chronic syndrome whose main symptom is the widespread pain caused by both allodynia and hyperalgesia [1]. The FM clinic includes a myriad of physical disturbances like joint stiffness, muscular twitches, burning skin, headaches or gastrointestinal alterations, as well as several psychological disorders and cognitive difficulties [2]. This syndrome can be considered as a highly disabling condition that affects to 0.2–6.6% of the general population [3], with an estimated healthcare cost over 5000€ per patient every year [4]. Apart from neurological causes, there are a number of molecular disturbances that have been studied in different models In this context, the role of oxidative stress has been recursively highlighted by scientific literature. In FM patients, there is an increased oxidative stress [8] and a compromised antioxidant defence in terms of low levels of reducing compounds such as ceruloplasmin

Methods

Results

Conclusion