Abstract
A histochemical method was used for the detection and localization of Δ5-3β- and 17β-hydroxysteroid dehydrogenase activity in the epitheliochorial placenta of the domestic pig, Sus scrofa. Placentas were obtained from the fourth week of gestation until term (114 days) and showed much the same substrate specificity throughout pregnancy. Both dehydroepiandrosterone and 3β,17β-dihydroxyandrost-5-ene (androstenediol) were better substrates than pregnenolone, particularly in the earlier stages. 17α- Hydroxypregnenolone was not utilized. With testosterone and estradiol-17β as substrates, the presence of both neutral and phenolic 17β-hydroxysteroid dehydrogenase enzymes could be demonstrated. No activity was seen with estradiol- 17α. The significance of these findings is discussed in relation to the possible role of the placenta in estrogen production in the sow. (Endocrinology 84: 426, 1969)
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