Abstract
1. 1. Tail tips from normal and hypophysectomized R. pipiens tadpoles, grown in vitro and in vivo, were analyzed at weekly intervals for protein and hydroxyproline content. 2. 2. Soluble hydroxyproline content of tails varied directly with the growth rate of intact and hypophysectomized tadpoles. 3. 3. Treatment in vivo and in vitro with propylthiouracil caused existing collagen to become more soluble, indicating a direct tissue effect. 4. 4. Methimazole, administered in vivo or in vitro tail cultures, had no effect upon existing collagen but did depress protein synthesis in vitro. 5. 5. Alterations in tail collagen in the hypothyroid tadpole appear to be sequelae of an impaired growth rate rather than due to direct effects upon collagen metabolism.
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