Abstract
IN plants and animals hydroxyproline hydroxyl oxygen is derived from the direct fixation of molecular oxygen1–4. It was therefore reasonable to propose that the mechanism of this oxygen fixation was analogous to those steroid hydroxylations which involve displacement of a single proton with retention of configuration5–8. One way of testing this proposal appeared to be opened by the availability of 3–4 tritiated proline. Determination of the tritium lost during hydroxylation should indicate the number of protons displaced. Two groups of workers have recently published the results of their experiments with 3–4 3H proline9–12.
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