Abstract
AbstractThe overcoming of thermodynamic limitations in the synthesis of optically active ketone cyanohydrins by using organic solvent‐free systems has been investigated. Therefore, substrates with known unfavorable results within hydroxynitrile lyase‐catalyzed reactions were selected for the determination of limitations and bottlenecks in ketone cyanohydrin synthesis. The highly (S)‐selective hydroxynitrile lyase from Manihot esculenta (MeHNL) has been chosen for the conversion of acetophenone and the corresponding derivatives, which are substrates that exhibit only low grades of conversion also with several other hydroxynitrile lyases. With organic solvent‐free systems under optimized reaction conditions conversions up to 78 % with>99.0 ee (S) were obtained. Finally, 5 mL of (S)‐acetophenone cyanohydrin with an enantiomeric excess of 98.5 % ee (S) were synthesized.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
